Human Endometrial Transcriptomics: Implications for Embryonic Implantation

Uterine fibroids are the most common benign tumors of the female genital tract. The management of symptomatic fibroids has traditionally been surgical; however, alternative pharmacological approaches have been proposed to control symptoms. To date, gonadotropin-releasing hormone analogs are the only available drugs for the preoperative treatment of fibroids.

Objective To compare the assessment of endometrial maturation parameters in endometrial secretion samples obtained by a novel minimally invasive technique with those assessed in tissue biopsies. Design Prospective study. Setting University Hospital. Population Healthy female volunteers.

To review the literature for studying the mechanisms of influence of superovulation on the receptivity of the endometrium in vitro fertilization IVF , which is largely due not only to the quality of the embryo, but with the condition of the endometrium, its maturity and readiness for implantation. In the course of acquaintance with the publication presents the morphological characteristics of the endometrium in stimulated cycles.

Presents current views on endometrial receptivity and the molecular mechanisms regulation of implantation. The features of the expression of estrogen and progesterone receptors, as well as other markers of endometrial receptivity pinopodii, leukemia inhibitory factor, integrins in natural and stimulated cycles. Patients with a history of failure of implantation prior to IVF ART program is necessary to analyze all inducers affecting the endometrium, endometrial morphological landscape, E2 receptor expression and progesterone pinopodii, integrins, molecular and genetic aspects of the endometrium in stimulated cycles.

The analysis of numerous publications showing an adverse effect on superovulation endometrial receptivity in assisted reproduction programs. Undetermined noninvasive markers to assess the receptivity of the endometrium, including in stimulated cycles. Not evaluated linically significant endometrial threshold level of progesterone on the day of ovulation trigger and insufficiently studied the possible mechanisms of the effect of a premature increase of progesterone on the outcomes of IVF.

Therefore, further study and development of the best approaches for the prevention and correction of the negative impact of ovarian stimulation function on the endometrium in assisted reproduction programs. Keywords IVF; premature luteinization stimulated cycle; endometrial receptivity; receptors estradiol; progesterone receptors; integrins; pinopodii; leukemia inhibitory factor expression of Noja Full Text: Assisted reproductive technology in Europe, European Society of Human Reproduction and Embriology: